Raman optical activity of small organic molecules

Author: Mgr. Markéta Kubáňová
Supervisor: Prof. RNDr. Vladimír Baumruk, DrSc.
Type: Bachelor

Abstract: Raman optical activity is a modern spectroscopic method applicable to a huge range of molecules. It measures a difference in the scattered light from chiral molecules with respect to right- and left-circularly polarized light. Raman optical activity is a very sensitive method that can provide more detailed stereochemical information than the standard techniques. In this work we measured Raman optical activity of small chiral molecules (camphor, fenchone) in selected standard organic solvents (carbon tetrachloride, chloroform, acetonitrile) at different concentrations (0.25 M, 0.5 M, 1.0 M and 1.2 M). From obtained results we can decide which solvents and which sample concentrations are suitable for obtaining ROA spectra of sufficient quality.

Keywords: Raman optical activity, organic solvents, small chiral molecules