Division of Biomolecular Physics
Institute of Physics
Charles University, Ke Karlovu 5, Prague 2, 121 16
tel.: +420 221 911 345, fax: +420 224 922 797
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Fields of interest

  • Structure, dynamics and formation of spatial motifs of nucleic acids, poly-stranded complexes and nucleic acid-enzyme interactions important for oligonucleotide therapy.

  • Formation of complexes of cationic metalloporphyrins with nucleic acids, their physico-chemical properties in ground and excited electronic state and potential application on transport of oligonucleotides into cells.

  • Structure of proteins and their interaction with ligands.

  • Structure and conformational flexibility of (bio)molecules in solution: application of Raman optical activity (ROA). Simulations of Raman and ROA spectra.

  • Surface enhanced Raman scattering (SERS) spectroscopy of biomolecules. Preparation and physico-chemical properties of SERS–active systems.

  • Computer modelling of structure and function of biomolecules: application of molecular-dynamics simulations, ab initio quantum chemistry calculations, homology modelling and molecular docking.

  • Microfluorescence techniques for monitoring of penetration and distribution of potential chemotherapeutics in cells.

  • Medical applications of optical spectroscopy.

  • UV resonance Raman spectroscopy of biomoleculs

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