Fields of interest

Structure, dynamics and formation of spatial motifs of nucleic acids, poly-stranded complexes and nucleic acid-enzyme interactions important for oligonucleotide therapy.
Formation of complexes of cationic metalloporphyrins with nucleic acids, their physico-chemical properties in ground and excited electronic state and potential application on transport of oligonucleotides into cells.
Structure of proteins and their interaction with ligands.
Structure and conformational flexibility of (bio)molecules in solution: application of Raman optical activity (ROA). Simulations of Raman and ROA spectra.
Surface enhanced Raman scattering (SERS) spectroscopy of biomolecules. Preparation and physico-chemical properties of SERS–active systems.
Computer modelling of structure and function of biomolecules: application of molecular-dynamics simulations, ab initio quantum chemistry calculations, homology modelling and molecular docking.
Microfluorescence techniques for monitoring of penetration and distribution of potential chemotherapeutics in cells.
Medical applications of optical spectroscopy.
UV resonance Raman spectroscopy of biomoleculs